Mouse Genome Informatics
hm
    Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• periorbital fullness is a characteristic of these mice
• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth
• 20% of mice have a twisted snout
• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees
• mice have a characteristically short snout

growth/size/body
• 20% of mice have a twisted snout
• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees
• mice have a characteristically short snout
• body weight of 1- and 2- month old mice that have properly aligned jaws is a few grams less than controls
• weights of mice with misaligned jaws is dramatically less

skeleton
• periorbital fullness is a characteristic of these mice
• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth

behavior/neurological
• the 20% of mice with malocclusions are unable to manipulate hard food pellets
• mice display an abnormal clasping or kicking behavior upon lifting

vision/eye
• periorbital fullness is a characteristic of these mice

Mouse Models of Human Disease
OMIM IDRef(s)
Williams-Beuren Syndrome; WBS 194050 J:102709