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Phenotypes Associated with This Genotype
Genotype
MGI:3820200
Allelic
Composition
Gtf2ird1Tg(Alb1-Myc)166.8Sst/Gtf2ird1Tg(Alb1-Myc)166.8Sst
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtf2ird1Tg(Alb1-Myc)166.8Sst mutation (0 available); any Gtf2ird1 mutation (327 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• periorbital fullness is a characteristic of these mice
• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth
• 20% of mice have a twisted snout
• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees
• mice have a characteristically short snout

growth/size/body
• 20% of mice have a twisted snout
• in these severely affected mice, the snout is twisted to the left or right by 7 to 12 degrees
• mice have a characteristically short snout
• body weight of 1- and 2- month old mice that have properly aligned jaws is a few grams less than controls
• weights of mice with misaligned jaws is dramatically less

skeleton
• periorbital fullness is a characteristic of these mice
• 20% of mice have a misaligned jaw resulting in chronic overgrowth of teeth

behavior/neurological
• the 20% of mice with malocclusions are unable to manipulate hard food pellets
• mice display an abnormal clasping or kicking behavior upon lifting

vision/eye
• periorbital fullness is a characteristic of these mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Williams-Beuren Syndrome; WBS 194050 J:102709


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory