Analysis Tools
neoplasm
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• three weeks after zinc administration through drinking water, the first signs of hepatic neoplasia are evident with large hepatocytes with compact nuclei being found around blood vessels
• after six weeks of zinc administration, 80% of mice display these neoplastic lesions
• after ten weeks of zinc administration, foci of dysplastic cells are found throughout the liver nodule
• intravascular spread of tumor cells is also observed ten weeks after zinc administration
• after 16 weeks of zinc administration, over 70% of mice carry single or multifocal nodules of which one quarter consist of well differentiated hepatocellular carcinomas displaying pseudoglandular or trabecular pattern
• the appearance of preneoplastic and neoplastic lesions also occur in mice with a delay of 6 to 8 weeks in mice not receiving zinc treatment
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liver/biliary system
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• three weeks after zinc administration through drinking water, the first signs of hepatic neoplasia are evident with large hepatocytes with compact nuclei being found around blood vessels
• after six weeks of zinc administration, 80% of mice display these neoplastic lesions
• after ten weeks of zinc administration, foci of dysplastic cells are found throughout the liver nodule
• intravascular spread of tumor cells is also observed ten weeks after zinc administration
• after 16 weeks of zinc administration, over 70% of mice carry single or multifocal nodules of which one quarter consist of well differentiated hepatocellular carcinomas displaying pseudoglandular or trabecular pattern
• the appearance of preneoplastic and neoplastic lesions also occur in mice with a delay of 6 to 8 weeks in mice not receiving zinc treatment
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