Phenotypes Associated with This Genotype

Genotype
MGI:3819147

• Allelic Composition: Dst^dt/Dst^dt
• Genetic Background: involves: Q

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:5674 )

• originally some mice survive for months but successive generations exhibit lethality by 3 to 4 weeks of age

behavior/neurological

limb grasping ( J:5674 )

dystonia ( J:5674 )

impaired limb coordination ( J:5674 )

• mice alternate between hyperextension and hyperflexion of the limbs but no paralysis is evident

nervous system

neurodegeneration ( J:5674 )

• the nervous system shows degenerative changes and progressive loss of nerve fibers in the central and peripheral branches of the sensory ganglion cells of the spinal and cranial nerves, in the central sensory pathways, and in peripheral sensory structures such as skin, Pacinian corpuscles, and muscle spindles

• in animals that survive longer there is also evidence of lower motor neuron involvement

muscle

dystonia ( J:5674 )