Phenotypes Associated with This Genotype

Genotype
MGI:3818948

• Allelic Composition: Pparg^tm1Tka/Pparg^tm1Tka
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:58222 )

• mice die between E10.5 and E11.5

• in vitro fertilized embryos transplanted in pseudopregnant females survive until E13.5

embryo

embryonic growth retardation ( J:58222 )

abnormal placenta labyrinth morphology ( J:58222 )

• lumps of cells and fibrinoid materials are found within the labyrinth layer unlike in wild-type mice

abnormal placental labyrinth vasculature morphology ( J:58222 )

• embryonic capillaries are poorly developed within the labyrinth layer compared to in wild-type mice

placental labyrinth hypoplasia ( J:58222 )

• at E10.5

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:58222 )

• embryonic capillaries are poorly developed within the labyrinth layer compared to in wild-type mice

thin myocardium ( J:58222 )

abnormal heart development ( J:58222 )

• at E10.5, no marked trabeculation occurs as in wild-type mice

cellular

abnormal cell differentiation ( J:58222 , J:89250 )

• embryonic fibroblasts fail to differentiate into adipose cells unlike wild-type embryonic fibroblast cells (J:58222)

• treatment with pioglitazone does not rescue differentiation of embryonic fibroblasts into adipocytes unlike in heterozygous cells (J:58222)

• embryonic stem cells fail to differentiate into adipose cells in culture but osteogenesis is enhanced unlike wild-type cells (J:89250)

growth/size/body

embryonic growth retardation ( J:58222 )

muscle

thin myocardium ( J:58222 )