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Phenotypes Associated with This Genotype
Genotype
MGI:3818937
Allelic
Composition		 Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
Genetic
Background		 involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (1 available); any Aire mutation (55 available)
Airetm2Mmat mutation (2 available); any Aire mutation (55 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:141379 )
N
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

hematopoietic system
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

endocrine/exocrine glands
abnormal thymus morphology ( J:141379 )
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory