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Phenotypes Associated with This Genotype
Genotype
MGI:3818603
Allelic
Composition
Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg16l1Gt(BC0122)Wtsi mutation (1 available); any Atg16l1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls

homeostasis/metabolism
• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice

cellular
• autophagy by the ileal epithelium and thymocytes is severely reduced in these mice

endocrine/exocrine glands
• aberrant, disorganized granules as well as decreased granule numbers are observed in these mice
• virtually all Paneth cells have lysozyme localized throughout the cell instead of being discretely packaged within vesicles
• Paneth cells also have degenerating mitochondria, loss of granules and the frequent absence of apical microvilli
• adjacent crypt lumen often contains intact Paneth granules and cytoplasm, which is a phenomenon not observed in wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
inflammatory bowel disease 10 DOID:0110885 OMIM:611081
J:141419


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory