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Phenotypes Associated with This Genotype
Genotype
MGI:3818534
Allelic
Composition
Coro1aptcd/Coro1atm1Achn
Genetic
Background
B6.Cg-Coro1aptcd Coro1atm1Achn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coro1aptcd mutation (0 available); any Coro1a mutation (10 available)
Coro1atm1Achn mutation (0 available); any Coro1a mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls
• CD4+ T cell numbers in the periphery are significantly decreased around 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased
• T cells have defects in migrating on ICAM-coated surfaces
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included

hematopoietic system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls
• CD4+ T cell numbers in the periphery are significantly decreased around 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased
• T cells have defects in migrating on ICAM-coated surfaces
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included

endocrine/exocrine glands
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory