Mouse Genome Informatics
ht
    Coro1aptcd/Coro1atm1Achn
B6.Cg-Coro1aptcd Coro1atm1Achn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls
• CD4+ T cell numbers in the periphery are significantly decreased around 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased
• T cells have defects in migrating on ICAM-coated surfaces
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included

hematopoietic system
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice
• migrating T cells have irregularly shaped protrusions that are often larger in size than controls
• CD4+ T cell numbers in the periphery are significantly decreased around 5-fold
• CD8+ T cell numbers in the periphery are significantly decreased
• T cells have defects in migrating on ICAM-coated surfaces
• upon CD3 activation, T cells flux less Ca2+ than wild-type controls
• however, similar Ca2+ flux results as controls are observed when CD4 stimulation is included

endocrine/exocrine glands
• the percentage of mature (CD69loCD62Lhi) single-positive thymocytes is increased in these mice

Mouse Models of Human Disease
OMIM IDRef(s)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive 608971 J:141431