Phenotypes Associated with This Genotype

Genotype
MGI:3818486

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tyrobp^tm1.1Viv/Tyrobp^tm1.1Viv
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone trabecula number ( J:129304 )

• the number of trabeculae are increased compared to wild-type mice

• however, trabecular thickness is normal

increased trabecular bone connectivity density ( J:129304 )

• the space between trabeculae is reduced compared to in wild-type mice

increased bone mass ( J:129304 )

• bone mass is increased 30% compared to in Tyrobp^tm1.1Viv homozygotes and 60% compared to in wild-type mice and Rag1^tm1Mom homozygotes

osteopetrosis ( J:129304 )

• severe

abnormal bone remodeling ( J:129304 )

• following ovariectamy, mice exhibit an increased bone loss compared to in similarly treated wild-type mice or Tyrobp^tm1.1Viv homozygotes

abnormal osteoclast physiology ( J:129304 )

• collagen type I degradation products are decreased 17% compared to in wild-type mice

immune system

abnormal osteoclast physiology ( J:129304 )

• collagen type I degradation products are decreased 17% compared to in wild-type mice

hematopoietic system

abnormal osteoclast physiology ( J:129304 )

• collagen type I degradation products are decreased 17% compared to in wild-type mice