craniofacial
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
• some mice are missing the incisors
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
• some mice exhibit a loss of the third molar
|
skeleton
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
• some mice are missing the incisors
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
• some mice exhibit a loss of the third molar
|
endocrine/exocrine glands
• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
|
anhidrosis
(
J:140329
)
• mice produce no sweat
|
integument
• mice produce no sweat and lack sweat glands as in EdaTa homozygotes
|
anhidrosis
(
J:140329
)
• mice produce no sweat
|
• mice possess only awl hairs
|
• mice exhibit a bald patch at the top of the vertex that is expanded in some mice into the neck and extends laterally in a symmetrical pattern
• alopecia is evident at the time of first hair emergence and not associated with sex, age or hair cycling
|
• compared to in EdaTa homozygotes
|
• mice lack primary and secondary hair follicles
• at E18, follicle development in the center of the cranium is absent
• however, treatment with Eda-A1 restores secondary hair follicles
|
growth/size/body
• mice exhibit one incisor and three molars in each quarter of the jaw unlike in wild-type mice
|
• some mice are missing the incisors
|
• molars exhibit a reduced number of cusps compared to in wild-type mice
|
• some mice exhibit a loss of the third molar
|