Phenotypes Associated with This Genotype

Genotype
MGI:3818258

• Allelic Composition: Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs
• Genetic Background: B6.Cg-Scn8a^med-TgA4Bs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye electrophysiology ( J:110231 )

• retinal ganglion cells exhibit a subtle but significant decrease in repetitive spikes fired during depolarization compared to in wild-type cells

• retinal ganglion cells firing rates fail to increased between P12 and P18 as in wild-type mice

• retinal ganglion cells are less able to generate spikes at short interspike intervals after depolarization compared to wild-type cells and achieve spike failure sooner than in wild-type cells