Phenotypes Associated with This Genotype

Genotype
MGI:3818256

• Allelic Composition: Scn8a^med-TgA4Bs/Scn8a^med-TgA4Bs
• Genetic Background: involves: C3H * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:24228 )

• mice die by 25 days of age

behavior/neurological

limb grasping ( J:24228 )

impaired balance ( J:24228 )

• 11 days after birth

hindlimb paralysis ( J:24228 )

• 14 days after birth

muscle

muscular atrophy ( J:24228 )

growth/size/body

decreased body weight ( J:24228 )

nervous system

nervous system phenotype ( J:24228 )

N • despite abnormal behavior and muscle loss, mice exhibit normal numbers of motor neurons in the spinal cord