Phenotypes Associated with This Genotype

Genotype
MGI:3818171

• Allelic Composition: Scn8a^med/Scn8a⁺
• Genetic Background: C3Fe.Cg-Scn8a^med/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:129998 )

• following exposure to flurothyl, mice exhibit a 25% increase in latency to myoclonic jerk and a 58% increase in latency to generalized tonic-clonic seizure (GTCS) compared to in similarly treated wild-type mice

• following exposure to kainic acid, mice exhibit reduced seizure severity and no GTCS compared to similarly treated wild-type mice

abnormal spike wave discharge ( J:147199 )

• mice exhibit spike wave discharge (SWD) accompanied by behavior arrest unlike wild-type mice

• the average incidence of SWD is higher than in Scn8a^med heterozygotes but lower than in Scn8a^8J heterozygotes

• ethosuximide treatment results in 11-fold fewer and shorter SWD compared to a 3-fold increase in frequencies following saline treatment

• the frequency of SWD during slow-wave sleep and paradoxical SWD are higher during the dark cycle than during the light cycle

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:129998 )

• following exposure to flurothyl, mice exhibit a 25% increase in latency to myoclonic jerk and a 58% increase in latency to generalized tonic-clonic seizure (GTCS) compared to in similarly treated wild-type mice

• following exposure to kainic acid, mice exhibit reduced seizure severity and no GTCS compared to similarly treated wild-type mice

abnormal spike wave discharge ( J:147199 )

• mice exhibit spike wave discharge (SWD) accompanied by behavior arrest unlike wild-type mice

• the average incidence of SWD is higher than in Scn8a^med heterozygotes but lower than in Scn8a^8J heterozygotes

• ethosuximide treatment results in 11-fold fewer and shorter SWD compared to a 3-fold increase in frequencies following saline treatment

• the frequency of SWD during slow-wave sleep and paradoxical SWD are higher during the dark cycle than during the light cycle