Phenotypes Associated with This Genotype

Genotype
MGI:3818076

• Allelic Composition: Scn8a^dmu/Scn8a^med
• Genetic Background: involves: C3H * C3HeB/Fe * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:71615 )

• mice do not survive beyond weaning

muscle

dystrophic muscle ( J:71615 )

• beginning at 2 weeks of age although a few days later than in Scn8a^dmu homozygotes

behavior/neurological

abnormal voluntary movement ( J:71615 )

• similar to Scn8a^med homozygotes, mice are prone to positioning themselves on their side and wriggling

hindlimb paralysis ( J:71615 )

• at 2 weeks of age mice exhibit a progressive loss of mobility in their hindlimbs