Phenotypes Associated with This Genotype

Genotype
MGI:3818069

• Allelic Composition: Scn8a^med-J/Scn8a^med-J; Scnm1^s/Scnm1^s
• Genetic Background: involves: C57BL/6J * STOCK Krt71^Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141236 )

• mice survive one month

muscle

muscle weakness ( J:141236 )

• mice exhibit muscle weakness but retain hindlimb function

cellular

abnormal cell physiology ( J:141236 )

• mice exhibit reduced splicing of the Scn8a^med-J transcript compared to in wild-type mice