Phenotypes for Scn8a Scnm1 MGI:3818067 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Scn8a^med-J/Scn8a^med-J Scnm1^tm1.1Mm/Scnm1^tm1.1Mm
Genetic Background	involves: C57BL/6 * FVB * SJL * STOCK Krt71^Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^med-J mutation (2 available); any Scn8a mutation (101 available)
Scnm1^tm1.1Mm mutation (0 available); any Scnm1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:141236 )

behavior/neurological

hindlimb paralysis ( J:141236 )

• in all mice

cellular

abnormal cell physiology ( J:141236 )

• mice exhibit reduced splicing of the Scn8a^med-J transcript compared to in wild-type mice and Scn8a^med-J Scnm1^s double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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