Phenotypes Associated with This Genotype

Genotype
MGI:3817913

• Allelic Composition: Atoh7^{tm1(Neurod1)Whk}/Atoh7^{tm2(Neurod4)Whk}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:141248 )

N • mice exhibit normal numbers of bipolar, Muller glial and amacrine cells

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

increased retina photoreceptor cell number ( J:141248 )

• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

nervous system

increased retina photoreceptor cell number ( J:141248 )

• the number of opsin+ photoreceptors is increased by 20% compared to in wild-type mice

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, one-third of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

cellular

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice