Phenotypes Associated with This Genotype

Genotype
MGI:3817863

• Allelic Composition: \Tg(CD2-Zbtb7b)C8Rbo/?; \Tg(TcrLCMV)327Sdz/?
• Genetic Background: involves: C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:97610 )

• mice have substantial numbers of transgenic CD4⁺ T cells while having a complete absence of transgenic CD8⁺ T cells, which is a reversal of the T cell populations that normally develop in mice carrying just the Tg(TcrLCMV)327Sdz allele

• the CD4 T cells bear high levels of the transgenic TCR, express CD154 upon activation, and have other hallmarks (lack perforin and IFN-gamma expression) of truly belonging to the CD4 lineage and not the CD8 lineage

hematopoietic system

abnormal T cell differentiation ( J:97610 )

• mice have substantial numbers of transgenic CD4⁺ T cells while having a complete absence of transgenic CD8⁺ T cells, which is a reversal of the T cell populations that normally develop in mice carrying just the Tg(TcrLCMV)327Sdz allele

• the CD4 T cells bear high levels of the transgenic TCR, express CD154 upon activation, and have other hallmarks (lack perforin and IFN-gamma expression) of truly belonging to the CD4 lineage and not the CD8 lineage