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Phenotypes Associated with This Genotype
Genotype
MGI:3817861
Allelic
Composition
Tg(CD2-Zbtb7b)C8Rbo/?
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background
involves: C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CD2-Zbtb7b)C8Rbo mutation (0 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• female mice have substantial numbers of HY-specific CD4+ T cells while having a complete absence of HY-specific CD8+ T cells, which is a reversal of the T cell populations that normally develop in female mice carrying just the Tg(TcraH-Y,TcrbH-Y)71Vbo allele

hematopoietic system
• female mice have substantial numbers of HY-specific CD4+ T cells while having a complete absence of HY-specific CD8+ T cells, which is a reversal of the T cell populations that normally develop in female mice carrying just the Tg(TcraH-Y,TcrbH-Y)71Vbo allele


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory