Phenotypes Associated with This Genotype

Genotype
MGI:3817859

• Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD4-positive, alpha-beta T cell number ( J:97610 )

• CD4 T cell numbers are almost doubled in the spleen

absent CD8-positive, alpha-beta T cells ( J:97610 )

• CD8 T cells are virtually absent in the periphery (less than 1% of controls)

• single positive CD8⁺ TCR^hi thymocytes are also less than 1% of controls

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:97610 )

• CD4 T cell numbers are almost doubled in the spleen

absent CD8-positive, alpha-beta T cells ( J:97610 )

• CD8 T cells are virtually absent in the periphery (less than 1% of controls)

• single positive CD8⁺ TCR^hi thymocytes are also less than 1% of controls