Phenotypes Associated with This Genotype

Genotype
MGI:3817750

• Allelic Composition: Gpc3^tm1Fil/Gpc3^tm1Fil
• Genetic Background: B6.Cg-Gpc3^tm1Fil

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:73877 )

♀ • phenotype is stated to be similar to that of Gpc3^tm1Fil male hemizygotes; however, no data are presented in J:73877

craniofacial

mandible hypoplasia ( J:73877 )

♀

digestive/alimentary system

abnormal perineum morphology ( J:73877 )

♀ • mutant females with an imperforate vagina display swelling of the perineum

reproductive system

abnormal perineum morphology ( J:73877 )

♀ • mutant females with an imperforate vagina display swelling of the perineum

dilated uterus ( J:73877 )

♀ • mutant females with an imperforate vagina have a dilated, fluid-filled uterus

vagina atresia ( J:73877 )

♀ • mutant females exhibit an imperforate vagina at a higher frequency (30%) than wild-type females (4%)

immune system

lung inflammation ( J:73877 )

♀

increased susceptibility to bacterial infection ( J:73877 )

♀

renal/urinary system

kidney cyst ( J:73877 )

♀

abnormal kidney development ( J:73877 )

♀

abnormal ureteric bud morphology ( J:73877 )

♀

impaired branching involved in ureteric bud morphogenesis ( J:73877 )

♀

respiratory system

lung inflammation ( J:73877 )

♀

skeleton

mandible hypoplasia ( J:73877 )

♀

growth/size/body

increased body weight ( J:73877 )

♀

kidney cyst ( J:73877 )

♀