Phenotypes Associated with This Genotype

Genotype
MGI:3817509

• Allelic Composition: Lmna^tm1Lgf/Lmna^tm1Lgf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lmna^tm1Lgf/Lmna^tm1Lgf mice are small and have poorly mineralized bone

mortality/aging

premature death ( J:113119 )

• all mice die by 3 to 4 weeks of age

skeleton

abnormal skeleton morphology ( J:113119 )

• mice develop fractures in the extremities

abnormal cranium morphology ( J:113119 )

wide cranial sutures ( J:113119 )

• mice have open sutures

micrognathia ( J:113119 )

decreased bone mineralization ( J:113119 )

• mice exhibit poor bone mineralization

adipose tissue

decreased total body fat amount ( J:113119 )

• mice lack adipose tissue

cellular

abnormal cell nucleus morphology ( J:113119 , J:141165 )

• mouse embryonic fibroblasts exhibit more misshapen nuclei than in wild-type cells (J:113119)

• however, the frequency of misshapen nuclei is reduced following treatment with FTI (a farnesyltransferase inhibitor) (J:113119)

• mouse embryonic fibroblasts exhibit more misshapen nuclei than in wild-type or Lmna^tm1Lgf heterozygotes (J:141165)

growth/size/body

decreased body size ( J:113119 )

• mice are half the size of wild-type mice

craniofacial

abnormal cranium morphology ( J:113119 )

wide cranial sutures ( J:113119 )

• mice have open sutures

micrognathia ( J:113119 )