Phenotypes for Isl1 Pou4f1 MGI:3817489 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Isl1^tm1Tmj/Isl1^tm1Tmj Pou4f1^tm1Et/Pou4f1^tm1Et
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1Tmj mutation (1 available); any Isl1 mutation (38 available)
Pou4f1^tm1Et mutation (0 available); any Pou4f1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:141110 )

• embryonic lethality occurs at E10.5

embryo

embryonic growth arrest ( J:141110 )

• growth arrest occurs about E9.5

nervous system

abnormal brain development ( J:141110 )

• dorsal fore-brain and midbrain are lost due to necrosis at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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