Phenotypes Associated with This Genotype

Genotype
MGI:3817420

• Allelic Composition: Sting1^tm1Gnb/Sting1^tm1Gnb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal innate immunity ( J:141011 )

• mouse embryonic fibroblasts (MEF) are defective in initiating immune defenses (i.e. interferon-beta induction ) in response to negative strand viruses such as vesicular stomatitis virus (VSV) and the Sendai virus or the DNA herpes simplex virus 1

• b-form DNA, interferon stimulatory DNA, and the bacteria Listeria monocytogenes also fail to elicit a response in mutant MEFs

abnormal susceptibility to Herpesvirales infection ( J:141011 )

• MEFs produce less interferon-beta in response to herpes simplex-1 virus

increased susceptibility to Riboviria infection ( J:141011 )

• MEFs infected with vesicular stomatitis virus (VSV) have 100-fold higher titer number than controls 24 to 36 hours after infection

• MEFs produce less interferon-beta in response to VSV and the Sendai viruses

• less susceptibility to VSV is observed in bone marrow-derived dendritic cells or macrophages