Analysis Tools
growth/size/body
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• at 3 months of age, mice display a mild decrease in body weight compared to wild-type mice
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nervous system
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• agouti-related protein expressing neurons are slightly more hyperpolarized than in wild-type mice and do not respond electrophysically to glucose as do wild-type cells
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behavior/neurological
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• following treatment with melanotan II, mice exhibit less food intake than similarly treated wild-type
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homeostasis/metabolism
| N |
• despite reduction in weight, mice exhibit normal food intake, resting metabolic rate, daily energy expenditure, response to a high fat diet, leptin, glucose and adiponectin levels, and glucose and insulin tolerance
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