Phenotypes Associated with This Genotype

Genotype
MGI:3817275

• Allelic Composition: Edil3^tm1Tq/Edil3^tm1Tq
• Genetic Background: B6.129S6-Edil3^tm1Tq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

abnormal neutrophil physiology ( J:141063 )

• enhanced neutrophil recruitment occurs in these mice with higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

cellular

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

hematopoietic system

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

abnormal neutrophil physiology ( J:141063 )

• enhanced neutrophil recruitment occurs in these mice with higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice