Phenotypes Associated with This Genotype

Genotype
MGI:3817273

• Allelic Composition: Mecp2^tm1.1Bird/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:135824 )

♂ • male mutants become considerably heavier than littermates after 2 months, with noticeable weight differences at 9 weeks

♂ • at 17 weeks, males 39.7 g vs 32.1 g in wild-type

obese ( J:135824 )

♂ • male mice become obese with increased weight of fat pads by 14-17 weeks

behavior/neurological

behavior/neurological phenotype ( J:135824 )

♂N • visual placing reflex and response to a soft touch to the side of the face are normal relative to wild-type

♂N • olfaction and motivation to eat were normal in mutants

♂N • anxiety-related behaviors are similar to wild-type mice

♂N • ability to grip a wire and remain suspended for 1 minute is normal in mutants

limb grasping ( J:135824 )

♂ • subtle clasping is observed starting at 6 weeks of age

abnormal motor coordination/balance ( J:135824 )

♂

abnormal social investigation ( J:135824 )

♂ • mutants spend less time in chamber side containing familiar mouse than in side with a stranger relative to controls, although response to introduction of stranger is similar

adipose tissue

increased total fat pad weight ( J:135824 )

♂ • fat pads in 14-17 week old male mice weigh 2-3 times more than wild-type