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Phenotypes Associated with This Genotype
Genotype
MGI:3817270
Allelic
Composition
Ift20tm1.1Gjp/Ift20tm1.1Gjp
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift20tm1.1Gjp mutation (1 available); any Ift20 mutation (20 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• by P23, collecting duct cells lacking cilia show increased rates of proliferation
• by P23 most of the kidney is replaced by collecting duct epithelium, fluid filled cysts, and fibrotic material
• at E18 collecting duct epithelial cells almost completely lack cilia
• cystic expansion of the collecting ducts
• cells lining cysts lack primary cilia
• cells lining cysts may be flat with prominent microvilli or domed with less pronounced microvilli
• progressive bilateral kidney enlargement beginning by P10
• by P23, kidney weight is about 10 times that of controls
• at E18 collecting duct epithelial cells almost completely lack cilia
• at P5 in non-dilated tubules, mitotic spindle orientation is randomized rather than being parallel to the long axis of the tubule
• at P5 the centrosome remains at the apical end of the cell but can be located anywhere from the lateral junction to the center of the cell rather than at the center of the cell
• dilation is first seen at P5

homeostasis/metabolism
• about 3 times higher than in controls

cellular
• at E18 collecting duct epithelial cells almost completely lack cilia
• by P23, collecting duct cells lacking cilia show increased rates of proliferation

growth/size/body
• cystic expansion of the collecting ducts
• cells lining cysts lack primary cilia
• cells lining cysts may be flat with prominent microvilli or domed with less pronounced microvilli
• progressive bilateral kidney enlargement beginning by P10
• by P23, kidney weight is about 10 times that of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory