Phenotypes Associated with This Genotype

Genotype
MGI:3817236

• Allelic Composition: Mecp2^tm1.1Bird/Mecp2⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:194039 )

♀ • decrease in the number of ATRX containing foci in null cells only

abnormal cerebral cortex morphology ( J:194039 )

♀ • decrease in the number of ATRX containing foci in null cells only

decreased neuron number ( J:108953 )

♀ • 7-9 week old adults have 33% the number of Mecp2-expressing neurons compared to young adult wild-type

♀ • compared to age-matched wild-type adults, 24-95 week old heterozygotes have 68% the number of Mecp2-expressing cortical neurons; number of Mecp2-expressing neurons is significantly higher in younger mutants than in older mutants

cellular

abnormal dosage compensation, by inactivation of X chromosome ( J:108953 )

♀ • X-chromosome inactivation becomes unbalance in older mutants, with a larger percentage expressing Mecp2 compared to younger mutants (>50%)