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Phenotypes Associated with This Genotype
Genotype
MGI:3815318
Allelic
Composition		 Cd36tm1Frm/Cd36tm1Frm
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd36tm1Frm mutation (0 available); any Cd36 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:80658 )
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 80% compared to in wild-type cells
abnormal chemokine level ( J:80658 )
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type

homeostasis/metabolism
abnormal chemokine level ( J:80658 )
• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type

hematopoietic system
abnormal macrophage physiology ( J:80658 )
• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 80% compared to in wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory