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Phenotypes Associated with This Genotype
Genotype
MGI:3815301
Allelic
Composition
Tsc1tm1Djk/Tsc1tm1Djk
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)LC1Bjd/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax8-rtTA2S*M2)1Koes mutation (2 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
Tsc1tm1Djk mutation (1 available); any Tsc1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys

renal/urinary system
• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:140925


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory