Mouse Genome Informatics
cn
    Tsc1tm1Djk/Tsc1tm1Djk
Tg(Pax8-rtTA2S*M2)1Koes/0
Tg(tetO-cre)LC1Bjd/0

involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys

renal/urinary system
• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:140925