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Phenotypes Associated with This Genotype
Genotype
MGI:3815198
Allelic
Composition
ArTfm/Y
Tg(TSPY)9Jshm/0
Genetic
Background
involves: NMRI * STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (3 available); any Ar mutation (17 available)
Tg(TSPY)9Jshm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

neoplasm
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

endocrine/exocrine glands
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory