Mouse Genome Informatics
cx
    ArTfm/Y
Tg(TSPY)9Jshm/0

involves: NMRI * STOCK EdaTa Atp7aMo-blo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

tumorigenesis
• 3 of 31 mice exhibit unilateral Leydig tumor unlike ArTfm male mice on the original stock background
• however, no germ cell tumors are observed

endocrine/exocrine glands
• mice exhibit greater thickening and hyperplasia of peritubular myoid cells compared to ArTfm male mice on the original stock background
• unlike ArTfm male mice on the original stock background
• in 8 of 31 mice unlike ArTfm male mice on the original stock background
• compared to ArTfm male mice on a mixed NMRI and stock of origin background

Mouse Models of Human Disease
OMIM IDRef(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803