Phenotypes Associated with This Genotype

Genotype
MGI:3815131

• Allelic Composition: Sptlc2^tm1Jia/Sptlc2⁺
• Genetic Background: B6.Cg-Sptlc2^tm1Jia

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:140627 )

• mice have decreased liver levels of sphingolipids including derivatives of ceramide and sphingosine

• however, mice have normal liver levels sphingosine-1-phosphate

abnormal circulating lipid level ( J:140627 )

• mice have decreased plasma levels of sphingolipids including ceramide and sphingosine-1-phosphate derivatives

• lysosphingomyelin is especially affected with a 16.4 fold reduction in the plasma level

• levels of sphingomyelin derivatives are normal