Phenotypes Associated with This Genotype

Genotype
MGI:3815087

• Allelic Composition: Agrp^tm1(cre)Lowl/Agrp⁺; Slc32a1^tm1Lowl/Slc32a1^tm1Lowl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:140858 )

• absent in AgRP neurons

growth/size/body

decreased body weight ( J:140858 )

• in both males and females on a normal chow diet

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

adipose tissue

decreased total body fat amount ( J:140858 )

• decrease in weight gain on a high fat diet is solely the result of reduced fat accumulation

behavior/neurological

abnormal food intake ( J:140858 )

• attenuated response to gherlin induced increase in food intake

• however, no difference in baseline food intake is detected

increased locomotor activity ( J:140858 )

• increased locomotor activity

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

increased oxygen consumption ( J:140858 )

• on a normal chow diet

• during the transition from a normal chow diet to a high fat diet there is a larger increase in oxygen consumption compared to controls

decreased respiratory quotient ( J:140858 )

• reduced