Analysis Tools
mortality/aging
|
• on a congenic B6 background, a portion of homozygotes die between E15.5 and E18.5, while approximate Mendelian ratios are obtained at and before E14.5
• Background Sensitivity: on a mixed 129 x B6 background, homozygotes are born at the expected Mendelian frequency and survive to adulthood
• Background Sensitivity: the lethality observed on a congenic B6 background is completely rescued by a single outcross with CD1 mice
|
|
• on a congenic B6 background, fewer than expected homozygotes are obtained during the first 2 postnatal weeks
|
renal/urinary system
kidney cyst
(
J:118154
)
|
• on a congenic B6 background, many homozygotes display severe unilateral or bilateral cystic kidneys as early as 3 weeks of age
• Background Sensitivity: on a mixed 129 X B6 background, severe cystic kidneys are only detected in mice older than 3 weeks of age and are always unilateral
• >90% of surviving homozygotes on a B6 congenic background exhibit enlarged, fluid-filled kidneys, with epithelial cysts first noted at E17
|
homeostasis/metabolism
|
• on a congenic B6 background, >50% of homozygotes show no sign of barrier acquisition at E16.5 while 100% display only partial dye extrusion at E17.5; this is in contrast to wild-type littermates, all of which show precocious sites of dye extrusion at E16.5 and are fully resistant to dye penetration by E17.5
• no obvious dye penetration defects are noted at E18.5 or birth, suggesting that homozygotes are delayed in their barrier acquisition by ~1 day
|
integument
|
• on a congenic B6 background, >50% of homozygotes show no sign of barrier acquisition at E16.5 while 100% display only partial dye extrusion at E17.5; this is in contrast to wild-type littermates, all of which show precocious sites of dye extrusion at E16.5 and are fully resistant to dye penetration by E17.5
• no obvious dye penetration defects are noted at E18.5 or birth, suggesting that homozygotes are delayed in their barrier acquisition by ~1 day
|
growth/size/body
kidney cyst
(
J:118154
)
|
• on a congenic B6 background, many homozygotes display severe unilateral or bilateral cystic kidneys as early as 3 weeks of age
• Background Sensitivity: on a mixed 129 X B6 background, severe cystic kidneys are only detected in mice older than 3 weeks of age and are always unilateral
• >90% of surviving homozygotes on a B6 congenic background exhibit enlarged, fluid-filled kidneys, with epithelial cysts first noted at E17
|
