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Phenotypes Associated with This Genotype
Genotype
MGI:3815023
Allelic
Composition
Fmr1tm2Cgr/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmr1tm2Cgr mutation (2 available); any Fmr1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 72 weeks, male mice (106 to 123 CGG repeats) in an open field test travel shorter distances and enter the center circle fewer times than wild-type mice
• however, activity and exploration levels are normal
• at 52 weeks, male mice (106 to 123 CGG repeats) in a Morris water maze exhibit impaired visual-spatial learning and memory compared to wild-type mice with increased escape latency and path length
• male mice (106 to 123 CGG repeats) exhibit decreased performance on a rotarod as they age unlike wild-type mice
• at 52 and 72 weeks, male mice (106 to 123 CGG repeats) exhibit reduced latency to fall on a rotarod test compared to at 20 weeks of age
• at 72 weeks, male mice (106 to 123 CGG repeats) exhibit a lower number of segments crossed on a stationary beam compared to wild-type mice
• however, mice perform as wild-type mice in a gait test
• at 52 weeks, male mice (106 to 123 CGG repeats) exhibit decreased latency to first fall in a wire suspension test and fall more often than wild-type mice
• however, performance in a wire suspension test is normal at 20 and 72 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fragile X-associated tremor/ataxia syndrome DOID:0050879 OMIM:300623
J:104445


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory