Mouse Genome Informatics
hm
    Pde6gtm1Goff/Pde6gtm1Goff
either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• at 8 weeks of age, mice lack any photoreceptor layer
• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas
• most of the outer segment is lost by P13
• mice exhibit diminished a and b wave components compared to wild type mice with a delay in the b wave implicit time
• diminished eye electrophysiological response worsens with age

nervous system
• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas
• most of the outer segment is lost by P13

Mouse Models of Human Disease
OMIM IDRef(s)
Retinitis Pigmentosa; RP 268000 J:33048