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Phenotypes Associated with This Genotype
Genotype
MGI:3814998
Allelic
Composition
Pde6gtm1Goff/Pde6gtm1Goff
Genetic
Background
either: (involves: 129S/SvEv * C57BL/6 * MF1 * Swiss Webster) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * MF1 * Swiss Webster)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde6gtm1Goff mutation (0 available); any Pde6g mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 8 weeks of age, mice lack any photoreceptor layer
• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas
• most of the outer segment is lost by P13
• mice exhibit diminished a and b wave components compared to wild type mice with a delay in the b wave implicit time
• diminished eye electrophysiological response worsens with age

nervous system
• between P14 and P21 mice exhibit a progressive loss of photoreceptors that is more severe in central areas of the retina than in peripheral areas
• most of the outer segment is lost by P13

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa; RP 268000 J:33048


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory