Phenotypes Associated with This Genotype

Genotype
MGI:3814909

• Allelic Composition: Cd19^tm1Tft/Cd19^tm1Tft
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:27236 )

• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes

• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice

• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice

decreased B-1 B cell number ( J:27236 )

• in the peritoneum

abnormal B cell physiology ( J:27236 )

• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice

• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4

decreased IgA level ( J:27236 )

• levels in unimmunized mice are 48% lower than in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 86% lower than in wild-type mice

decreased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% lower than in wild-type mice

decreased IgG2b level ( J:27236 )

• levels in unimmunized mice are 72% lower than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 57% lower than in wild-type mice

decreased IgM level ( J:27236 )

• levels in unimmunized mice are 75% lower than in wild-type mice

hematopoietic system

decreased B cell number ( J:27236 )

• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes

• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice

• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice

decreased B-1 B cell number ( J:27236 )

• in the peritoneum

abnormal B cell physiology ( J:27236 )

• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice

• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4

decreased IgA level ( J:27236 )

• levels in unimmunized mice are 48% lower than in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 86% lower than in wild-type mice

decreased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% lower than in wild-type mice

decreased IgG2b level ( J:27236 )

• levels in unimmunized mice are 72% lower than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 57% lower than in wild-type mice

decreased IgM level ( J:27236 )

• levels in unimmunized mice are 75% lower than in wild-type mice

cellular

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4