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Phenotypes Associated with This Genotype
Genotype
MGI:3814906
Allelic
Composition
Six3tm4(cre/ERT2)Gco/Six3+
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six3tm4(cre/ERT2)Gco mutation (0 available); any Six3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Background Sensitivity: 16% display a phenotype typical of holoprosencephaly after one backcross to C57BL/6
• Background Sensitivity: after two additional backcrosses to C57BL/6, 85% show a holoprosencephaly phenotype

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 2; HPE2 157170 J:140315


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory