Mouse Genome Informatics
ht
    Six3tm4(cre/ERT2)Gco/Six3+
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• Background Sensitivity: 16% display a phenotype typical of holoprosencephaly after one backcross to C57BL/6
• Background Sensitivity: after two additional backcrosses to C57BL/6, 85% show a holoprosencephaly phenotype

Mouse Models of Human Disease
OMIM IDRef(s)
Holoprosencephaly 2; HPE2 157170 J:140315