Phenotypes Associated with This Genotype

Genotype
MGI:3814894

• Allelic Composition: Pdcd1^tm1Hon/Pdcd1^tm1Hon; Tg(Tcra2D2,Tcrb2D2)1Kuch/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:140751 )

• in conjunction with anti-CTLA-4 antibody treatment, mice exhibit reduced paralysis induced by experimental autoimmune encephalomyelitis (EAE) compared to wild type mice

• however, adoptive transfer of Gt(ROSA)26Sor^tm2Awai Cd19^tm1(cre)Cgn double heterozygous B cells increases paralysis induced by EAE despite treatment with anti-CTLA-4 antibodies compared to wild-type mice receiving Gt(ROSA)26Sor^tm2Awai Cd19^tm1(cre)Cgn double heterozygous B cells