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Phenotypes Associated with This Genotype
Genotype
MGI:3814892
Allelic
Composition		 Gt(ROSA)26Sortm2.1(Cd74/MOG)Awai/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2.1(Cd74/MOG)Awai mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:140751 )
• antigen producing cells are capable of inducing proliferation of CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch in vitro unlike wild-type cells
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:140751 )
• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory