Phenotypes Associated with This Genotype

Genotype
MGI:3814827

• Allelic Composition: Stk11^tm1.2Rdp/Stk11⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:134476 )

• mice die at average age of 12.5 months

digestive/alimentary system

gastrointestinal tract polyps ( J:134476 )

• 100% of animals have gastrointestinal polyps at 11 months

• average polyp size is larger than in Stk11-conditional mutants

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls

neoplasm

increased gastrointestinal tumor incidence ( J:134476 )

• tumor formation (polyposis) in the gastrointestinal tract is increased greatly relative to controls