Phenotypes Associated with This Genotype

Genotype
MGI:3814562

• Allelic Composition: Fos^tm1Mxu/Fos^tm1Mxu; Tg(Camk2a-cre)T50Stl/0
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:108041 )

• population spike amplitude evoked by minimal stimulation intensity is significantly larger in hippocampal mutant slices compared to wild-type slices with a large increase in cellular excitability and a larger maximal response

• >60% of slices show epileptiform activity following low intensity stimulation compared to <40% of wild-type

• very low concentration kainic acid (KA) stimulation of hippocampal slices produces maximal CA3 population spike amplitude and higher concentrations induces severe epileptiform activity, reducing amplitude of the population response