Phenotypes Associated with This Genotype

Genotype
MGI:3814534

• Allelic Composition: Stk11^tm1.2Rdp/Stk11^tm1.2Rdp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:78818 )

• lethality manifests at about E8.5-E11

embryo

abnormal placenta development ( J:78818 )

• placental development is abnormal

cardiovascular system

abnormal vasculogenesis ( J:78818 )

• embryos display defects in vasculogenesis

cellular

abnormal cell physiology ( J:78818 )

• at low densities, cells do not form colonies efficiently

abnormal cell cycle ( J:78818 )

• MEFs prepared from mutant embryos cultured under 3T9 or 3T3 protocols show a consistent increase in G1 content and a reciprocal reduction in G2

• MEFs fail to undergo growth arrest at later passages in contrast to wild-type and heterozygous MEFs, showing unabated growth after 40 doublings