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Phenotypes Associated with This Genotype
involves: 129S2/SvPas * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm2Tyj mutation (1 available); any Kras mutation (30 available)
Trp53tm1Glo mutation (0 available); any Trp53 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• average lifespan is 266 days with female mice exhibiting shorter lifespans than male mice

• lung adenocarcinomas and mesothelioma are highly invasive and metastatic with metastatic lesions observed in the lymph nodes and liver
• 19 of 52 mice with lung adenocarcinomas exhibit metastasis compared to only 2 of 44 Krastm2Tyj heterozygotes
• 81.8% of mice with end-stage lung adenocarcinomas exhibit loss of heterozygosity of the Trp53 wild-type allele
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, pancreatic carcinomas, squamous carcinomas, and papillomas
• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas
• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated
• some mice develop lung lymphomas
• 13 of 56 mice develop mesothelioma 6 of which are peritoneal mesotheliomas

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:129627

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory