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Phenotypes Associated with This Genotype
Genotype
MGI:3814436
Allelic
Composition
Krastm2Tyj/Kras+
Trp53tm1Glo/Trp53+
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm2Tyj mutation (1 available); any Kras mutation (36 available)
Trp53tm1Glo mutation (0 available); any Trp53 mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas
• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated

mortality/aging
• average lifespan is 266 days with female mice exhibiting shorter lifespans than male mice

neoplasm
• 81.8% of mice with end-stage lung adenocarcinomas exhibit loss of heterozygosity of the Trp53 wild-type allele
• lung adenocarcinomas and mesothelioma are highly invasive and metastatic with metastatic lesions observed in the lymph nodes and liver
• 19 of 52 mice with lung adenocarcinomas exhibit metastasis compared to only 2 of 44 Krastm2Tyj heterozygotes
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, pancreatic carcinomas, squamous carcinomas, and papillomas
• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas
• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated
• some mice develop lung lymphomas
• 13 of 56 mice develop mesothelioma 6 of which are peritoneal mesotheliomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:129627


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory