Mouse Genome Informatics

involves: 129S2/SvPas * 129S7/SvEvBrd
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• average lifespan is 266 days with female mice exhibiting shorter lifespans than male mice

• lung adenocarcinomas and mesothelioma are highly invasive and metastatic with metastatic lesions observed in the lymph nodes and liver
• 19 of 52 mice with lung adenocarcinomas exhibit metastasis compared to only 2 of 44 Krastm2Tyj heterozygotes
• 81.8% of mice with end-stage lung adenocarcinomas exhibit loss of heterozygosity of the Trp53 wild-type allele
• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, pancreatic carcinomas, squamous carcinomas, and papillomas
• 52 of 56 mice develop atypical adenamatous hyperplasia, adenomas and adenocarcinomas
• most mice develop multiple large or diffuse adenocarcinomas that have glandular phenotypes or are poorly differentiated
• some mice develop lung lymphomas
• 13 of 56 mice develop mesothelioma 6 of which are peritoneal mesotheliomas

Mouse Models of Human Disease
Lung Cancer 211980 J:129627