Phenotypes Associated with This Genotype

Genotype
MGI:3814332

• Allelic Composition: Sesn2^{Gt(RRJ141)Byg}/Sesn2^{Gt(RRJ141)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal autophagy ( J:189021 )

• in mice fed a high fat diet and less so when fed a low fat diet, lipid droplets exhibit less association of autophagic vesicles with lipid droplets compared to in control mice

abnormal gluconeogenesis ( J:189021 )

• mice fed a high fat diet exhibit reduced hepatic glucose production during hyperinsulinemic-euglycemic clamp compared with control mice

impaired glucose tolerance ( J:189021 )

• when fed a high fat diet

insulin resistance ( J:189021 )

• when fed a high fat diet, mice exhibit impaired insulin responsiveness in liver and adipose tissue compared with control mice

• however, AMPK activation restores insulin sensitivity

increased liver triglyceride level ( J:189021 )

• slightly in lean mice

• substantially in mice fed a high fat diet

• however, hepatic restoration of AMPK restoration reduces triglyceride accumulation in mice fed a high fat diet

cellular

decreased adipocyte glucose uptake ( J:189021 )

• impaired in mice fed a high fat diet

decreased hepatocyte mitochondrial DNA content ( J:189021 )

• in the liver of mice fed a high fat diet

decreased mitochondrial number ( J:189021 )

• in the liver of mice fed a high fat diet

abnormal autophagy ( J:189021 )

• in mice fed a high fat diet and less so when fed a low fat diet, lipid droplets exhibit less association of autophagic vesicles with lipid droplets compared to in control mice

liver/biliary system

decreased hepatocyte mitochondrial DNA content ( J:189021 )

• in the liver of mice fed a high fat diet

increased liver triglyceride level ( J:189021 )

• slightly in lean mice

• substantially in mice fed a high fat diet

• however, hepatic restoration of AMPK restoration reduces triglyceride accumulation in mice fed a high fat diet

macrovesicular hepatic steatosis ( J:189021 )

• increased lipid droplets with increased size in mice fed a high fat diet

adipose tissue

decreased adipocyte glucose uptake ( J:189021 )

• impaired in mice fed a high fat diet

growth/size/body

growth/size/body region phenotype ( J:189021 )

N • mice fed a high fat diet exhibit normal obesity