Phenotypes Associated with This Genotype

Genotype
MGI:3814239

• Allelic Composition: Atg5^tm1Nmz/Atg5^tm1Nmz; Tg(CAG-EGFP/Map1lc3b)53Nmz/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal autophagosome formation ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

mortality/aging

neonatal lethality, complete penetrance ( J:140583 )

• neonatal lethality occurs, caused in part by perinatal metabolic process

cellular

abnormal autophagosome formation ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

hematopoietic system

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes

immune system

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes

endocrine/exocrine glands

abnormal thymus morphology ( J:140583 )

• E15.5 thymus cells fail to form autophagosomes as occurs in the wild-type fetal thymus

abnormal thymus physiology ( J:140583 )

• embryonic thymi transplanted under the renal capsule of athymic hosts develop and release CD4 ⁺ T cells that mount an autoimmune attack

• this autoimmune attack leads to patches of flaky skin, a massively enlarged colon, atrophy of the uterus, complete absence of fat pads and in many cases enlarged lymph nodes