Phenotypes Associated with This Genotype

Genotype
MGI:3814076

• Allelic Composition: Rom1^Rgsc1156/Rom1⁺
• Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor outer segment ( J:158048 )

• at 7 weeks and worse at 35 weeks

• not as severe as in homozygotes

disorganized photoreceptor outer segment ( J:158048 )

thin retina outer nuclear layer ( J:158048 )

• at 7 weeks and worse at 35 weeks

• not as severe as in homozygotes

retina degeneration ( J:133634 )

• observed in founder mouse at 16 weeks of age

abnormal eye electrophysiology ( J:158048 )

• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age

• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system

short photoreceptor outer segment ( J:158048 )

• at 7 weeks and worse at 35 weeks

• not as severe as in homozygotes

disorganized photoreceptor outer segment ( J:158048 )