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Phenotypes Associated with This Genotype
Genotype
MGI:3813939
Allelic
Composition		 Il2rgtm1Wjl/Y
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Wjl mutation (84 available); any Il2rg mutation (177 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
thymus cyst ( J:140388 )
• thymus contains large cysts

immune system
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts
absent NK T cells ( J:140388 )
• natural killer cell (NK; DX5+LGL+ cells) are absent
decreased macrophage cell number ( J:140388 )
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
abnormal spleen morphology ( J:140388 )
• spleen contains mainly myeloid-like cells and few lymphoid cells
decreased spleen B cell follicle number ( J:140388 )
• spleen contains no follicles (or germinal centers)
abnormal adaptive immunity ( J:140388 )
• mature T and B cell populations are absent
• there are diminished CD3+CD4+ and CD3+CD8+ T cells and Igk+ light chain+ B cells in the spleen
abnormal innate immunity ( J:140388 )
• cells functioning in innate immunity are severely decreased in number
abnormal response to transplant ( J:140388 )
• irradiated mice engrafted with human hematopoietic stem cells (HSCs) show much greater engraftment of human hematopoietic cells at 12 weeks than control NOD.129S7(B6)-Rag1tm1Mom homozygotes
• percentages of human CD45+ cells engrafted in bone marrow are higher than in NOD.129S7(B6)-Rag1tm1Mom homozygotes
• levels of human CD45+ cell and CD3+ T cell engraftment are higher in spleens than in NOD.129S7(B6)-Rag1tm1Mom mice
• CD4:CD8 human T cell ratios that are close to normal physiological values and high levels of human B cells are observed in spleens of mice compared to NOD.129S7(B6)-Rag1tm1Mom mice
• engraftment of human lymphohematopoietic cells in blood and thymus, and peripheral blood mononuclear cells (PMBC) engraftment are higher than in NOD.129S7(B6)-Rag1tm1Mom mice

hematopoietic system
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts
absent NK T cells ( J:140388 )
• natural killer cell (NK; DX5+LGL+ cells) are absent
decreased macrophage cell number ( J:140388 )
• levels are Gr-1-ve Mac-1+ve macrophages are reduced
abnormal spleen morphology ( J:140388 )
• spleen contains mainly myeloid-like cells and few lymphoid cells
decreased spleen B cell follicle number ( J:140388 )
• spleen contains no follicles (or germinal centers)

endocrine/exocrine glands
abnormal thymus morphology ( J:140388 )
• no lymphoid cells are present
absent thymus cortex ( J:140388 )
• no defined cortical region is observed
absent thymus medulla ( J:140388 )
• no defined medullary region is observed
thymus cyst ( J:140388 )
• thymus contains large cysts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory