Analysis Tools
immune system
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• serum levels of IgGA in nave mice are lower than in controls
• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)
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• serum levels of IgG1 in nave mice are several log units lower than in controls
• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)
• similar defects are noted upon immunization with KLH
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• serum levels of IgG2a in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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• serum levels of IgG2b in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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• serum levels of IgG3 in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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• lymph nodes after immunization have barely recognizable, poorly organized germinal center-like areas with scattered apoptotic cells
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hematopoietic system
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• serum levels of IgGA in nave mice are lower than in controls
• similar defects are noted upon immunization with keyhole limpet hemocyanin (KLH)
|
|
• serum levels of IgG1 in nave mice are several log units lower than in controls
• these mice have severely impaired production of antigen-specific IgG1 after immunization with trinitrophenyl-conjugated chicken gamma-globulin (TNP-CGG)
• similar defects are noted upon immunization with KLH
|
|
• serum levels of IgG2a in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2a after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
|
|
• serum levels of IgG2b in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
|
|
• serum levels of IgG3 in nave mice are lower than in controls
• these mice have severely impaired production of antigen-specific IgG3 after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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• these mice have 10 to 20% of normal production levels of antigen-specific IgG2b after immunization with TNP-CGG
• similar defects are noted upon immunization with KLH
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