Phenotypes Associated with This Genotype

Genotype
MGI:3813545

• Allelic Composition: Cd79a^tm2Cgn/Cd79a^tm2Cgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

decreased mature B cell number ( J:66840 , J:71100 )

• the number of mature B cells found in the spleen is reduced by about 100-fold (J:66840)

• there is a 100-fold reduction in the number of recirculating mature B cells in the bone marrow and spleen (J:71100)

decreased pre-B cell number ( J:66840 , J:71100 )

• mice have a 50% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-B cells in the bone marrow (J:66840)

• few B cells progress through the IgM⁺B220⁺CD43^- immature stage (J:66840)

• there is a 10-fold reduction in the number of pre-B cells (B220^low CD43^- IgM^- ) found in bone marrow (J:71100)

• there is a 10-fold reduction in the number of immature-B cells (B220^low IgM⁺ IgD^-) found in bone marrow (J:71100)

immune system

increased pro-B cell number ( J:66840 )

• pro-B cell numbers are increased in the bone marrow

decreased mature B cell number ( J:66840 , J:71100 )

• the number of mature B cells found in the spleen is reduced by about 100-fold (J:66840)

• there is a 100-fold reduction in the number of recirculating mature B cells in the bone marrow and spleen (J:71100)

decreased pre-B cell number ( J:66840 , J:71100 )

• mice have a 50% decrease in IgM^-B220⁺CD43^-CD25⁺ pre-B cells in the bone marrow (J:66840)

• few B cells progress through the IgM⁺B220⁺CD43^- immature stage (J:66840)

• there is a 10-fold reduction in the number of pre-B cells (B220^low CD43^- IgM^- ) found in bone marrow (J:71100)

• there is a 10-fold reduction in the number of immature-B cells (B220^low IgM⁺ IgD^-) found in bone marrow (J:71100)